Poor Predictive Value of High-Sensitivity C-Reactive Protein Indicates Need for Reassessment

Poor predictive value of high-sensitivity C-reactive protein indicates need for reassessment.

Inflammation appears to be an integral part of the process of atherosclerosis that leads to coronary artery disease (CAD) and acute ischemic syndromes (1, 2). Data indicate that high-sensitivity C-reactive protein (hs-CRP) and other inflammatory markers are associated with atherosclerosis and that hs-CRP decreases with statin treatment (3, 4). These are important findings that support the infla...

Predictive ability of C-reactive protein for stroke

Prognostic value of C-Reactive Protein in Acute Coronary Syndromes

Introduction: Coronary artery disease (CAD) is among the most common, serious, chronic and life- threatening illnesses in the world. CAD represents a spectrum of conditions, with acute myocardial infarction at one end of it and silent ischemia at the other. There is growing evidence on importance of prognosis of C- reactive protein (CPR) in unstable angina and this protein is a maker of an adve...

High-sensitivity C-reactive protein: still need for next-generation biomarkers for remote future cardiovascular events.

Inflammation in the vessel wall plays a crucial role in the pathophysiology of atherogenesis, progression of atherosclerosis, and plaque instability. Atherosclerosis is initiated by dysfunction of endothelial cells (ECs), leading to expression of adhesion molecules for inflammatory cells. Vascular inflammation leads to an oxidizing environment due to activation of macrophages that secrete cytok...

Point: high-sensitivity C-reactive protein and cardiac C-reactive protein assays: is there a need to differentiate?

Recent evidence has shown that inflammation plays a pivotal role in the inception and progression of atherosclerosis, and population studies have demonstrated a strong and independent association between baseline concentrations of inflammatory biomarkers and future coronary events. Because the majority of individuals who develop coronary events are not in a high-risk group according to the Fram...